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Hereditary Cancer

A hereditary cancer is any cancer caused by a gene mutation

Overview

A hereditary cancer is any cancer caused by a gene mutation that is inherited over generations. A hereditary cancer panel can be selected in following cases:

  • Family history of cancer - Having 3 or more relatives on the same side of the family with the same or related forms of cancer
  • Cancer at an early age - Having 2 or more relatives diagnosed with cancer at an early age. This factor may differ depending on the type of cancer.
  • Multiple cancers- Having 2 or more types of cancer occurring in the same relative.

Test Details

A. Comprehensive Hereditary Cancer Panel (134 Genes)

Oncocliffe Comprehensive Hereditary Cancer panel targets more than 50 hereditary cancer syndromes. This panel is carefully curated to provide widest coverage of all pathologically relevant genes and disease relevant mutations by NGS. It provides a cost-effective alternative to single gene tests.

Genes Covered

AIPBRIP1EGFRFANCGMEN1NF2PTCH1SBDSSUFU
AKT1BUB1ELAC2FANCIMETNTRK1PTCH2SDHATERT
ALKBUB1BEPCAMFANCLMITFPALB2PTENSDHAF2TGFBR1
ANTXR1CACNA1DERCC2FANCMMLH1PALLDPTPN11SDHBTMEM127
APCCBLERCC3FHMLH3PDGFRBRAD50SDHCTP53
ASCC1CDC73ERCC4FLCNMRE11APHOX2BRAD51CSDHDTSC1
ATMCDH1ERCC5GPC3MSH2PIK3CARAD51DSETBP1TSC2
ATRCDK4EXT1HNF1AMSH6PMS2RB1SH2D1AVHL
AXIN2CDKN1BEXT2HNF1BMSR1POLD1RECQL4SLX4WAS
BAP1CDKN2AFANCAHOXB13MTAPPOLERETSMAD4WRN
BARD1CHEK2FANCBKDRMUTYHPOLHRHBDF2SMARCB1WT1
BLMCTHRC1FANCCKITMYH8PPM1DRNASELSMARCE1XPA
BMPR1ACYLDFANCD2KLLNNBNPRF1RNF168SPINK1XPC
BRCA1DDB2FANCELIG4NCOA4PRKAR1ARSPO1SPRED1XRCC2
BRCA2DICER1FANCFMAXNF1PRSS1RUNX1STK11

B. Oncocliffe Hereditary Breast Cancer Test

Genes Covered : BRCA1, BRCA2

Sample Type

3-5 ml EDTA blood / Purified Genomic DNA


Transportation

4-8℃


TAT

3-4 weeks

Tests

Test Code Description Methodology TAT Sample Details Transportation
RCL513 Oncocliffe Hereditary cancer panel (105 genes) NGS 30 Days Whole Blood/Purified genomic DNA 3-5 ml whole blood in EDTA vacutainer or 20-100 ng purified DNA
RCL514 Oncocliffe Comprehensive Cancer panel (400 genes) NGS 30 Days Whole Blood/Purified genomic DNA 3-5 ml whole blood in EDTA vacutainer or 20-100 ng purified DNA
RCL515 Oncocliffe Lynch syndrome/HNPCC gene Panel (MH1,MSH2,MSH6,PMS2,EPCAM) NGS 25 Days Whole Blood/Purified genomic DNA 3-5 ml whole blood in EDTA vacutainer or 20-100 ng purified DNA
RCL516 Oncocliffe BRCA1 & BRCA2 gene analysis (hereditary) NGS 25 Days Whole Blood/Purified genomic DNA 3-5 ml whole blood in EDTA vacutainer or 20-100 ng purified DNA