A hereditary cancer is any cancer caused by a gene mutation
A hereditary cancer is any cancer caused by a gene mutation that is inherited over generations. A hereditary cancer panel can be selected in following cases:
Oncocliffe Comprehensive Hereditary Cancer panel targets more than 50 hereditary cancer syndromes. This panel is carefully curated to provide widest coverage of all pathologically relevant genes and disease relevant mutations by NGS. It provides a cost-effective alternative to single gene tests.
Genes Covered
| AIP | BRIP1 | EGFR | FANCG | MEN1 | NF2 | PTCH1 | SBDS | SUFU |
| AKT1 | BUB1 | ELAC2 | FANCI | MET | NTRK1 | PTCH2 | SDHA | TERT |
| ALK | BUB1B | EPCAM | FANCL | MITF | PALB2 | PTEN | SDHAF2 | TGFBR1 |
| ANTXR1 | CACNA1D | ERCC2 | FANCM | MLH1 | PALLD | PTPN11 | SDHB | TMEM127 |
| APC | CBL | ERCC3 | FH | MLH3 | PDGFRB | RAD50 | SDHC | TP53 |
| ASCC1 | CDC73 | ERCC4 | FLCN | MRE11A | PHOX2B | RAD51C | SDHD | TSC1 |
| ATM | CDH1 | ERCC5 | GPC3 | MSH2 | PIK3CA | RAD51D | SETBP1 | TSC2 |
| ATR | CDK4 | EXT1 | HNF1A | MSH6 | PMS2 | RB1 | SH2D1A | VHL |
| AXIN2 | CDKN1B | EXT2 | HNF1B | MSR1 | POLD1 | RECQL4 | SLX4 | WAS |
| BAP1 | CDKN2A | FANCA | HOXB13 | MTAP | POLE | RET | SMAD4 | WRN |
| BARD1 | CHEK2 | FANCB | KDR | MUTYH | POLH | RHBDF2 | SMARCB1 | WT1 |
| BLM | CTHRC1 | FANCC | KIT | MYH8 | PPM1D | RNASEL | SMARCE1 | XPA |
| BMPR1A | CYLD | FANCD2 | KLLN | NBN | PRF1 | RNF168 | SPINK1 | XPC |
| BRCA1 | DDB2 | FANCE | LIG4 | NCOA4 | PRKAR1A | RSPO1 | SPRED1 | XRCC2 |
| BRCA2 | DICER1 | FANCF | MAX | NF1 | PRSS1 | RUNX1 | STK11 |
Genes Covered : BRCA1, BRCA2
3-5 ml EDTA blood / Purified Genomic DNA
4-8℃
3-4 weeks
| Test Code | Description | Methodology | TAT | Sample Details | Transportation | |
|---|---|---|---|---|---|---|
| RCL513 | Oncocliffe Hereditary cancer panel (105 genes) | NGS | 30 Days | Whole Blood/Purified genomic DNA | 3-5 ml whole blood in EDTA vacutainer or 20-100 ng purified DNA | |
| RCL514 | Oncocliffe Comprehensive Cancer panel (400 genes) | NGS | 30 Days | Whole Blood/Purified genomic DNA | 3-5 ml whole blood in EDTA vacutainer or 20-100 ng purified DNA | |
| RCL515 | Oncocliffe Lynch syndrome/HNPCC gene Panel (MH1,MSH2,MSH6,PMS2,EPCAM) | NGS | 25 Days | Whole Blood/Purified genomic DNA | 3-5 ml whole blood in EDTA vacutainer or 20-100 ng purified DNA | |
| RCL516 | Oncocliffe BRCA1 & BRCA2 gene analysis (hereditary) | NGS | 25 Days | Whole Blood/Purified genomic DNA | 3-5 ml whole blood in EDTA vacutainer or 20-100 ng purified DNA |