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Somatic Solid Cancer

Somatic cancer is a type of cancer that develops spontaneously in a tissue or organ

Overview

Oncocliffe Somatic mutations gene panels take a deeper view of variations in solid tumors including lung, colon, melanoma, gastric and ovarian cancers. This will help identify low frequency actionable somatic variations.

Test Details

A. Oncocliffe Somatic Cancer Hotspot Panel (50 Genes) - SNP and Indels

The Somatic Cancer Hostspot Panel analyses hotspot SNP and Indels in most relevant 50 genes associated with various cancers.

Genes Covered

EGFRGNAQKRASPTPN11
ERBB2GNASMETRB1
ERBB4HNF1AMLH1RET
EZH2HRASMPLSMAD4
FBXW7IDH1NOTCH1SMARCB1
FGFR1IDH2NPM1SMO
FGFR2JAK2NRASSRC
FGFR3JAK3PDGFRASTK11
FLT3KDRPIK3CATP53
GNA11KITPTENVHL

B. Oncocliffe Somatic Cancer Focus Assay: - SNPS, Indels, CNVs and Gene fusions

Oncocliffe Cancer Focus Assay is a unique multi biomarker assay offering SNP, Indels, CNV and Gene Fusions analysis in a single test. This test utilizes NGS with highly advanced bioinformatics analysis to analyze 4 different cancer biomarkers by same technology in a single workflow.This reduces the need for multiple test to identify same disorder thereby being time efficient, cost effective and offering peace of mind.

Genes Covered : 35 Genes for SNP, 19 Genes CNV, 23 Genes for Gene Fusions

Hotspot Genes Copy Number Variants Fusion Drivers
35 Genes 19 Genes 23 Genes
AKT1JAK1ALKABL1
ALKJAK2ARALK
ARJAK3BRAFAKT3
BRAFKITCCND1AXL
CDK4KRASCDK4BRAF
CTNNB1MAP2K1CDK6EGFR
DDR2MAP2K2EGFRERBB2
EGFRMETERBB2ERG
ERBB2MTORFGFR1ETV1
ERBB3NRASFGFR2ETV4
ERBB4PDGFRAFGFR3ETV5
ESR1PIK3CAFGFR4FGFR1
FGFR2RAF1KITFGFR2
FGFR3RETKRASFGFR3
GNA11ROS1METMET
GNAQSMOMYCNTRK1
HRASMYCNNTRK2
IDH1PDGFRANTRK3
IDH2PIK3CAPDGFRA
PPARG
RAF1
RET
ROS1

C. Oncocliffe Somatic Breast Cancer Theranostic Hotspot Panel (4 genes)

This panel identifies most common mutations in 4 genes associated with chemotherapeutic agents. It helps in better treatment by deciding proper medicine suitable to the patient.

Genes Covered : ERBB2, AKT1, PIK3CA and PTEN

D. Oncocliffe Non-Small Cell Lung Cancer (NSCLC) Hotspot Panel (8 Genes)

This panel identifies mutations relevant in 8 important genes associated with tumor progression and treatment in NSCLC.

Genes Covered : EGFR, KRAS, NRAS, HRAS, BRAF, PIK3CA, AKT1, HER2, and ALK

E. Oncocliffe Lung Hotspot and Fusion Assay

This assay analyses hotspot SNP, CNV and Fusion genes associated with Lung cancers.

Genes Covered : Hot spot (12 genes), CNV (MET), and fusion assay (ALK, RET, ROS)

F. Oncocliffe Breast Cancer Hotspot, Indels CNV Assay

Breast Cancer Hotspot assay analyzes for SNP, CNV and Indels 15 genes associated with development and progression of Breast Cancer.

Genes Covered : Hot spot (12 genes), CNVs (CCND1, ERBB2, FGFR1)

Sample Type

FFPE Block/ DNA/RNA extracted from relevant biopsy


Transportation

4-8℃


TAT

3-4 weeks

Tests

Test Code Description Methodology TAT Sample Details Transportation
RCL501 Oncocliffe Somatic Cancer hot spot panel - 50 major genes -SNPs NGS 25 Days FFPE Block/ Purified DNA from FFPE block or biopsy Minimum 2 FFPE blocks in a cardboard container or 20-50 ng purified DNA. Min. 10% of tumor tissue as assessed by pathologist should be available in each FFPE block.
RCL502 Oncocliffe Breast Cancer -Theranostic Hot spot panel ( 4 genes,ERBB2, AKT1,PIK3CA and PTEN) NGS 25 Days FFPE Block/ Purified DNA from FFPE block or biopsy Minimum 2 FFPE blocks in a cardboard container or 20-50 ng purified DNA. Min. 10% of tumor tissue as assessed by pathologist should be available in each FFPE block.
RCL503 Oncocliffe Non -small cell lung Cancer (NSCLC) hot spot panel (8 genes, EGFR, KRAS,NRAS,HRAS,BRAF,PIK3CA, AKT1,HER2, ALK) NGS 25 Days FFPE Block/ Purified DNA from FFPE block or biopsy Minimum 2 FFPE blocks in a cardboard container or 20-50 ng purified DNA. Min. 10% of tumor tissue as assessed by pathologist should be available in each FFPE block.
RCL504 Oncocliffe Cancer focus assay- SNPs, Indels,CNVs and gene fusions SNPs(35 genes), CNVs(19genes), Gene fusions(23 genes) - Single workflow - all in one NGS 30 Days FFPE Block/ Purified DNA from FFPE block or biopsy Minimum 2 FFPE blocks in a cardboard container or 20-50 ng purified DNA. Min. 10% of tumor tissue as assessed by pathologist should be available in each FFPE block.
RCL505 Oncocliffe Lung Hot spot and Fusion assay-Hot spot(12 genes), CNV(MET) and fusion assay(ALK, RET, ROS) NGS 30 Days FFPE Block/ Purified DNA from FFPE block or biopsy Minimum 2 FFPE blocks in a cardboard container or 20-50 ng purified DNA. Min. 10% of tumor tissue as assessed by pathologist should be available in each FFPE block.
RCL506 Oncocliffe Breast Cancer- Hot spot, indels, and CNV assay - Hot spot (12 genes)CNVs (CCND1,ERBB2,FGFR1. NGS 30 Days FFPE Block/ Purified DNA from FFPE block or biopsy Minimum 2 FFPE blocks in a cardboard container or 20-50 ng purified DNA. Min. 10% of tumor tissue as assessed by pathologist should be available in each FFPE block.
RCL507 Oncocliffe Somatic Cancer Comphrensive Gene Panel- 400 genes( SNP only) NGS 30 Days FFPE Block/ Purified DNA from FFPE block or biopsy Minimum 2 FFPE blocks in a cardboard container or 20-50 ng purified DNA. Min. 10% of tumor tissue as assessed by pathologist should be available in each FFPE block.